First Author (Year)	Churpek MM (2017) [22]
Title	qSOFA, SIRS, and early warning scores for detecting clinical deterioration in infected patients outside the ICU
Journal	American Journal of Respiratory and Critical Care Medicine
Reviewer	RL, KH, LL, MB, CG
Study sponsor	University of Chicago
Study type	Retrospective cohort (November 2008–January 2016)
Location	Chicago, USA
Participants Number Male/Female Age Patient group	150,288 identified, 30,677 analyzed 47% male Mean 58 years old (SD 18.0) All patients (ED and ward) outside of ICU with suspected infection
qSOFA criteria	Systolic blood pressure ≤100 mm Hg, respiratory rate ≥22 breaths per minute, and altered mental status (defined as either a Glasgow Coma Scale score ≤13 or an Alert Voice Pain Unresponsive scale (AVPU) other than “Alert”)
Primary outcome Other outcomes	In-hospital mortality composite of death or ICU stay
Results	In-hospital mortality AUC 0.69 (0.67–0.70)
Note