First Author (Year)	Donnelly JP (2017) [24]
Title	Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: A retrospective population-based cohort study
Journal	Lancet Infectious Disease
Reviewer	RL, KH, LL, MB, CG
Study sponsor	National Institute of Nursing Research; Center for Clinical and Translational Science and University of Alabama
Study type	Retrospective cohort (January 2003–October 2007)
Location	USA
Participants Number Male/Female Median age Patient group	22692 identified, 2593 analyzed 47.8% male 68 (61–75) Stroke study database; >45 years old; serious infection (defined as requiring admission), All patients (ICU, floor, or others)
qSOFA criteria	Altered mentation (Glasgow coma score <14 or deemed as non-alert on the alert, voice, pain, unresponsive scale), a systolic blood pressure of 100 mm Hg or lower, or respiratory rate of at least 22 breaths per min
Primary outcome Other outcomes	In-hospital mortality 28-day mortality and 1-year mortality
Results	0.759 AUC in-hospital mortality (Baseline plus qSOFA)
Note