First Author (Year)	Freund Y (2017) [28]
Title	Prognostic accuracy of sepsis-3 criteria for in-hospital mortality among patients with suspected infection presenting to the emergency department
Journal	JAMA
Reviewer	RL, KH, LL, MB, CG
Study sponsor	French Society of Emergency Medicine
Study type	Prospective cohort (16 May 16–16 June)
Location	International: France, Switzerland, Spain, Belgium
Participants Number Male/Female Median age (IQR) Patient group	1088 identified, 879 analyzed 53% male 67 (48–81) ED patients with clinical suspicion of infection
qSOFA criteria	Respiratory rate >21 breaths/min; Systolic arterial blood pressure ≤100 mm Hg; or altered mental status (determined clinically by the treating physician)
Primary outcome Other outcomes	In-hospital mortality Admission to ICU, length of ICU stay of more than 72 h, a composite of death, or ICU stay of more than 72 h
Results	In-hospital mortality AUC 0.80 (0.74–0.85) Sensitivity 70% (59–80), Specificity 79% (76–82), PPV 24% (18–30), NPV 97% (95–98)
Note