First Author (Year)	Giamarellos-Bournoulis EJ (2017) [29]
Title	Validation of the new Sepsis-3 definitions: Proposal for improvement in early risk identification
Journal	Clinical Microbiology and Infection
Reviewer	RL, KH, LL, MB, CG
Study sponsor	Hellenic Institute for the Study of Sepsis
Study type	Retrospective cohort (May 06–Decemeber 15)
Location	Greece
Participants Number Male/Female Median age Patient group	5176 identified, 4487 analyzed ? 76 (22) All patients with signs of infection of onset <24 h ago and at least two signs of SIRS
qSOFA criteria	GCS <13, RR>22, sBP <100
Primary outcome Other outcomes	Sensitivity of qSOFA and of the new sepsis definition to predict 28-day mortality To compare the performance of qSOFA and SIRS criteria for the early prediction of organ dysfunction outside the ICU, and to compare misclassification of severe cases by the 1991 definitions, and by Sepsis-3 definitions separately for non-ICU and ICU patients
Results	?
Note