First Author (Year)	April MD (2016) [16]
Title	Sepsis clinical criteria in emergency department patients admitted to an intensive care unit: An external validation study of quick sequential organ failure assessment
Journal	The Journal of Emergency Medicine
Reviewer	RL, KH, LL, MB, CG
Study sponsor	No information given
Study type	Retrospective cohort (August 2012–February 2015)
Location	Texas, USA
Participants Number Male/Female Median age (IQR) Patient group	321 identified, 214 analyzed 58.9% male 72 (60–79) ICU admission from ED with presumed sepsis; Patient with non-infectious etiology excluded
qSOFA criteria	Respiratory rate > 22 breaths/min; Glasgow Coma Scale < 14; Systolic blood pressure < 100 mm Hg
Primary outcome Other outcomes	Prognostic accuracy of qSOFA and SIRS for predicting in-hospital mortality (AUROC, sensitivity, specificity, and likelihood ratio) Assessment of the prognostic accuracy of LODS and SOFA criteria, using the same measures
Results	0.66 (95% CI 0.57–0.76) for qSOFA, 89.7% sensitivity, 27.4% specificity, 1.2 positive likelihood ratio, and 0.4 negative likelihood ratio