First Author (Year)	Henning DJ [33]
Title	An Emergency Department Validation of the SEP-3 Sepsis and Septic Shock Definitions and Comparison With 1992 Consensus Definitions
Journal	Annals of Emergency Medicine
Reviewer	RL, KH, LL, MB, CG
Study sponsor	Non stated
Study type	Prospectively Collected Data Retrospective Cohort (3 Decemeber–4 September, 5 September –6 September, 4 July–5 June)
Location	USA
Participants Number Male/Female Median age (SD) Patient group	7637 identified, 7754 analyzed 52.2% male 56.9 (20.8) All patients (ED, ward, ICU) with suspected infection
qSOFA criteria	Respiratory rate greater than or equal to 22 breaths/min, altered mental status (documented by physician), and hypotension defined by a systolic blood pressure of less than or equal to 100 mm Hg.
Primary outcome Other outcomes	All-cause in-hospital mortality, defined as death before hospital discharge. -
Results	AUC 0.77, Sens 52(46–57), Spec 86(85–87), PPV 14(13–15), NPV 98(98–98)
Note