Risk of Bias	Author’s Judgment Low Risk Unclear High Risk	Support for Judgment
Selection bias		Blood culture-positive only
Bias in definition and measurement		Altered mentation not defined in the original article, contacted author for clarification
Outcome measurement bias
Handling of missing data
Confounding
Bias of statistics or presentation of result		Limited statistics in the original paper. However the original author has supplied our team with de-personalized raw data for further data analysis