First Author (Year)	Ranzani (2017) [49]
Title	New Sepsis Definition (Sepsis-3) And Community-Acquired Pneumonia Mortality—A Validation and Clinical Decision-Making Study
Journal	American Journal of Respiratory and Critical Care Medicine
Reviewer	RL, CG, LL
Study sponsor	Centro de Investigacio’ n Biomedica En Red-Enfermedades Respiratorias and the European Respiratory Society Research Fellowships
Study type	Prospectively Collected Data Retrospective Cohort (1996–2015)
Location	Barcelona and Valencia
Participants Number Male/Female Mean Age (SD) Patient group	6874 62.2 Male Mean (66.1 (19)) Clinical diagnosis of CAP
qSOFA criteria	≥22 breaths/min, systolic blood pressure ≤100 mm Hg, altered mental status
Primary outcome Other outcomes	In-hospital mortality In-hospital mortality and/or need for critical support for three or more days, and 30-day mortality
Result	In-hospital mortality AUC 0.697 (0.671–0.722) qSOFA >2 Sn 50(45–55), Sp 81 (80–82), PPV 15 (13–17), NPV 96 (96–97), LR+ 2.70 (2.41–3.03), LR- 0.61 (0.55–0.68)
Note