First Author (Year)	Sterling (2017) [53]
Title	The Impact of the Sepsis-3 Septic Shock Definition on Previously Defined Septic Shock Patients.
Journal	Critical Care Medicine
Reviewer	RL, CG, LL
Study sponsor	Dr. Puskarich received support for article research from the National Institutes of Health (NIH), Dr. Guirgis’ institution received funding from the Society of Critical Care Medicine Vision Grant and from National Center for Advancing Translational Sciences through the University of Florida. Dr. Jones receives support through the National Institutes of General Medical Sciences (R01GM103799-01)
Study type	Secondary analysis of two previously completed clinical trials
Location	Large academic emergency departments in the United States.
Participants Number Male/Female Median age Patient group	470 (mean 60 ± 16.7) Patients with suspected infection, more than or equal to two systemic inflammatory response syndrome criteria, and systolic blood pressure of less than 90 mm Hg after fluid resuscitation.
qSOFA criteria	(respiratory rate ≥ 22 beats/min, altered mental status, or systolic blood pressure (SBP) of ≤ 100 mm Hg)
Primary outcome Other outcomes	In-hospital mortality
Results
Note	57% of patients meeting old definition for septic shock did not meet Sepsis-3 criteria