Table A1.
Studies Excluded.
| Author | Title | Decisions |
|---|---|---|
| Andaluz, D., Ferrer, R. | SIRS, qSOFA, and organ failure for assessing sepsis at the emergency department. | Excluded, no original data |
| April, M.D., Lantry, J.H. | Prognostic Accuracy of Quick Sequential Organ Failure Assessment Among Emergency Department Patients Admitted to an ICU. | Excluded, no original data |
| Asai, N., Watanabe, H., Shiota, A., et al. | Could qSOFA and SOFA score be correctly estimating the severity of healthcare-associated pneumonia? | Excluded, no original data |
| Atalan, H.K., Güçyetmez, B. | The effects of the chloride:sodium ratio on acid–base status and mortality in septic patients | Excluded, Study aim irrelevant |
| Awad, A. Bader-El-Den, M., McNicholas, J., et al. | Early hospital mortality prediction of intensive care unit patients using an ensemble learning approach. | Excluded, Study aim irrelevant |
| Becchi, C., Al Malyan, M., Fabbri, L.P., et al. | Mean platelet volume trend in sepsis: Is it a useful parameter? [Andamento del volume piastrinico medio in sepsi: Un parametro utile?] | Excluded, Study aim irrelevant |
| Bhattacharjee, P., Edelson, D.P., Churpek, M.M. | Identifying Patients with Sepsis on the Hospital Wards. | Excluded, no original data |
| Biyikli, E., Kayipmaz, A.E., Kavalci, C. | Effect of platelet–lymphocyte ratio and lactate levels obtained on mortality with sepsis and septic shock. | Excluded, Study aim irrelevant |
| Busani, S., Girardis, M. | PSP/reg: A new stone in sepsis biomarkers? | Excluded, Study aim irrelevant |
| Christ, M., Geier, F., Bertsch, T., et al. | Sepsis in Emergency Medicine. [German] | Language German |
| Cour, M., Hernu, R., Bénet, T., et al. | Benefits of smart pumps for automated changeovers of vasoactive drug infusion pumps: A quasi-experimental study | Excluded, Study aim irrelevant |
| David, N., Roux, N., Clavier, E., et al. | Open repair of extensive thoracoabdominal and thoracic aneurysm: A preliminary single-center experience with femorofemoral distal aortic perfusion with oxygenator and without cerebrospinal fluid drainage | Excluded, Study aim irrelevant |
| Desautels, T., Calvert, J., Hoffman, J., et al. | Prediction of Sepsis in the Intensive Care Unit with Minimal Electronic Health Record Data: A Machine Learning Approach. | Excluded, Study aim irrelevant |
| Dickmann, P., Scherag, A., Coldewey, S.M., et al. | Epistemology in the intensive care unit—What is the purpose of a definition? Paradigm shift in sepsis research | Language German |
| Du, B., Weng, L. | Systemic inflammatory response syndrome, sequential organ failure assessment, and quick sequential organ failure assessment: More pieces needed in the sepsis puzzle | Excluded, no original data |
| Edmark, C., McPhail, M.J.W., Bell, M., et al. | LiFe: A liver injury score to predict outcome in critically ill patients | Excluded, Study aim irrelevant |
| Fukushima, H., Kobayashi, M., Kawano, K., et al. | Performance of qSOFA and SOFA for predicting mortality in patients with acute pyelonephritis associated with upper urinary tract calculi. | Excluded. Patient too specific |
| Gerlach, H. | The new Sepsis 3 definition—a courageous approach | Language German |
| del Castillo, J.G., Carlota, C., Candel, F.J., et al. | New sepsis criteria: do they replace or complement what is known in the approach to the infectious patient? | Excluded, no original data |
| Gul, F., Arslantas, M.K., Cinel, I., et al. | Changing Definitions of Sepsis. [Review] | Excluded, no original data |
| Hou, P.C., Seethala, R.R., Aisiku, I.P. | qSOFA—Welcome to the sepsis alphabet soup | Excluded, no original data |
| Huson, M.A., Kalkman, R., Grobusch, M.P., et al. | Predictive value of the qSOFA score in patients with suspected infection in a resource limited setting in Gabon. | Excluded. Patient too specific |
| Huson, M.A.M., Katete, C., Chunda, L., et al. | Application of the qSOFA score to predict mortality in patients with suspected infection in a resource-limited setting in Malawi. | Excluded. Patient too specific |
| Jacob, J.A. | New sepsis diagnostic guidelines shift focus to organ dysfunction. | Excluded, no original data |
| Jawa, R.S., Vosswinkel, J.A., McCormack, J.E., et al. | Risk assessment of the blunt trauma victim: The role of the quick Sequential Organ Failure Assessment Score (qSOFA). | Excluded. Patient too specific |
| Julian-Jimenez, A., Yanez, M.C., Gonzalez-del Castillo, J., et al. | Prognostic power of biomarkers for short-term mortality in the elderly patients seen in Emergency Departments due to infections. [Spanish] | Language Spanish |
| Kim, M., Ahn, S., Kim, W.Y., et al. | Predictive performance of the quick Sequential Organ Failure Assessment score as a screening tool for sepsis, mortality, and intensive care unit admission in patients with febrile neutropenia. | Excluded. Patient too specific |
| Ladhani, H.A., Sajankila, N., Zosa, B.M., et al. | Utility of Sequential Organ Failure Assessment score in predicting bacteremia in critically ill burn patients. | Excluded. Patient too specific |
| Lebedev, N.V., Klimov, A.E., Agrba, S.B., et al. | [Combined forecasting system of peritonitis outcome]. [Russian] | Language Russian |
| Leclerc, F., Duhamel, A., Deken, V., et al. | Can the pediatric logistic organ dysfunction-2 score on day 1 be used in clinical criteria for sepsis in children? | Excluded. Patient too specific |
| Lee, S.J., Ramar, K., Park, J.G., et al. | Increased fluid administration in the first three hours of sepsis resuscitation is associated with reduced mortality: A retrospective cohort study | Excluded, Study aim irrelevant |
| Leidel, B.A. | The new Sepsis 3 definition—Flop or top? | Language German |
| Lemachatti, N., Freund, Y. | Sepsis: Definitions and validations. [French] | Language French |
| Maegele, M., Lefering, R., Yucel, N., et al. | Early coagulopathy in multiple injury: An analysis from the German Trauma Registry on 8724 patients | Excluded, Study aim irrelevant |
| Marik, P.E., Taeb, A.M. | SIRS, qSOFA, and new sepsis definition | Excluded, no original data |
| McCormack, D., Kulkarni, M., Keller, S.E. | Perspectives and implications of the new sepsis clinical practice guidelines. | Excluded, no original data |
| McLymont, N., Glover, G.W. | Scoring systems for the characterization of sepsis and associated outcomes. | Excluded, no original data |
| Moore, C.C., Hazard, R., Saulters, K.J., et al. | Derivation and validation of a universal vital assessment (UVA) score: a tool for predicting mortality in adult hospitalised patients in sub-Saharan Africa. | Excluded. Patient too specific |
| Patidar, K.R., Shaw, J., Acharya, C., et al. | No Association Between Quick Sequential Organ Failure Assessment and Outcomes of Patients With Cirrhosis and Infections. | Excluded. Patient too specific |
| Peach, BC. | Implications of the new sepsis definition on research and practice. | Excluded, no original data |
| Piano, S., Bartoletti, M., Tonon, M., et al. | Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections. | Excluded. Patient too specific |
| Rasulo, F.A., Bellelli, G., Ely, E.W., et al. | Are you Ernest Shackleton, the polar explorer? Refining the criteria for delirium and brain dysfunction in sepsis | Excluded, no original data |
| Rhee, C., Klompas, M. | New Sepsis and Septic Shock Definitions Clinical Implications and Controversies | Excluded, no original data |
| Ronco, C., Legrand, M., Goldstein, S.L., et al. | Neutrophil gelatinase-associated lipocalin: Ready for routine clinical use? An international perspective | Excluded, no original data |
| Rothman, M., Levy, M., Dellinger, R.P., et al. | Sepsis as 2 problems: Identifying sepsis at admission and predicting onset in the hospital using an electronic medical record-based acuity score | Excluded, Study aim irrelevant |
| Sager, R., Wirz, Y., Amin, D., et al. | Are admission procalcitonin levels universal mortality predictors across different medical emergency patient populations? Results from the multi-national, prospective, observational TRIAGE study. | Excluded, Study aim irrelevant |
| Scheer, C.S., Kuhn, S.O., Rehberg, S. | Use of the qSOFA score in the emergency department. | Excluded, no original data |
| Schlapbach, L.J., Straney, L., Bellomo, R., et al. | Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit. | Excluded. Patient too specific |
| Scott, M.C. | Defining and Diagnosing Sepsis. | Excluded, no original data |
| Seckel, M.A. | Sepsis-3: The new definitions. | Excluded, no original data |
| Seckel, M.A., Ahrens, T. | Challenges in Sepsis Care: New Sepsis Definitions and Fluid Resuscitation Beyond the Central Venous Pressure. | Excluded, no original data |
| Serafim, R., Gomes, J.A., Salluh, J., et al. | A comparison of the quick-SOFA (qSOFA) and SIRS criteria for the diagnosis of sepsis and prediction of mortality: A systematic review and meta-analysis. | Excluded, no original data |
| Shetty, A., MacDonald, S.P., Williams, J.M., et al. | Lactate ≥ 2 mmol/L plus qSOFA improves utility over qSOFA alone in emergency department patients presenting with suspected sepsis. | Excluded, Study aim irrelevant |
| Singer, M., Deutschman, C.S., Seymour, C., et al. | The third international consensus definitions for sepsis and septic shock (sepsis-3). | Excluded, no original data |
| Solligard, E., Damas, J.K. | SOFA criteria predict infection-related in-hospital mortality in ICU patients better than SIRS criteria and the qSOFA score. | Excluded, no original data |
| Viale, P., Tedeschi, S., Scudeller, L., et al. | Infectious diseases team for the early management of severe sepsis and septic shock in the emergency department | Excluded, Study aim irrelevant |
| Vincent, J.L., Grimaldi, D. | Quick sequential organ failure assessment: Big databases vs. intelligent doctors. | Excluded, no original data |
| Wang, A.Y., Ma, H.P., Kao, W.F., et al. | Red blood cell distribution width is associated with mortality in elderly patients with sepsis. | Excluded, Study aim irrelevant |
| Wang, H.E., Jones, A.R., Donnelly, J.P. | Revised National Estimates of Emergency Department Visits for Sepsis in the United States | Excluded, Study aim irrelevant |
| Zaccone, V., Tosoni, A., Passaro, G., et al. | Sepsis in Internal Medicine wards: Current knowledge, uncertainties and new approaches for management optimization. | Excluded, no original data |
| Zhou, X., Ding, B., Ye, Y., Tang, G., et al. | Authors respond to Both qSOFA score and bedside plasma lactate are the predictors of mortality for patients with infections in ED. | Excluded, no original data |
| Zhou, X., Tang, G. | Quick sepsis-related organ failure assessment (qSOFA) predicting outcomes in patients with infection, some lingering doubts. | Excluded, no original data |
| Zhou, X.D., Zhang, J.Y., Liu, W.Y., et al. | Quick chronic liver failure-sequential organ failure assessment: An easy-to-use scoring model for predicting mortality risk in critically ill cirrhosis patients | Excluded. Patient too specific |