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. 2019 Jan 21;8(1):126. doi: 10.3390/jcm8010126

Figure 3.

Figure 3

Distribution of rare variants among the 28 candidate genes in the different IHH groups. Showed according to the presence of obesity (A), age of IHH onset (B), TTe levels (C) and olfactory defects (D). IHH (isolated hypogonadotropic hypogonadism), AO (adult onset), PPO (prepubertal onset), mIHH (mild IHH), sIHH (severe IHH), KS (Kallmann’s Syndrome), nIHH (normoosmic IHH). Rare variants of ANOS1 were found only in two female controls; no male subject had a rare variant in ANOS1 among controls.