Table 3.
INRG neuroblastoma risk assignment table [5].
| INRG Stage | Age (Months) | Histology | Tumor Differentiation | MYCN Status | 11q Aberration | Ploidy | Risk Classification |
|---|---|---|---|---|---|---|---|
| L1/L2 | Any | Ganglioneuroma (GN) maturing Ganglioneuroblastoma (GNB) intermixed |
Any | Any | Any | Any | Very low |
| L1 | Any | Any except GN maturing or GNB intermixed | Any | Non-amplified | Any | Any | Very low |
| L1 | Any | Any except GN maturing or GNB intermixed | Any | Amplified | Any | Any | High |
| L2 | <18 | Any except GN maturing or GNB intermixed | Any | Non-amplified | No | Any | Low |
| L2 | <18 | Any except GN maturing or GNB intermixed | Any | Non-amplified | Yes | Any | Intermediate |
| L2 | ≥18 | GNB nodular, neuroblastoma | Differentiating | Non-amplified | No | Any | Low |
| L2 | ≥18 | GNB nodular, neuroblastoma | Differentiating | Non-amplified | Yes | Any | Intermediate |
| L2 | ≥18 | GNB nodular, neuroblastoma | Poorly differentiated, undifferentiated | Non-amplified | Any | Any | Intermediate |
| L2 | ≥18 | GNB nodular, neuroblastoma | Any | Amplified | Any | Any | High |
| M | <18 | Any | Any | Non-amplified | Any | Hyperdiploid | Low |
| M | <12 | Any | Any | Non-amplified | Any | Diploid | Intermediate |
| M | 12 to <18 | Any | Any | Non-amplified | Any | Diploid | Intermediate |
| M | <18 | Any | Any | Amplified | Any | Any | High |
| M | ≥18 | Any | Any | Any | Any | Any | High |
| MS | <18 | Any | Any | Non-amplified | No | Any | Very low |
| MS | <18 | Any | Any | Non-amplified | Yes | Any | High |
| MS | <18 | Any | Any | Amplified | Any | Any | High |
Reprinted with permission. © 2009 American Society of Clinical Oncology. All rights reserved. Cohn, S.L. et al.: J Clin Oncol, Vol. (27:2), 2009: page 295.