Table 1.
Patient baseline characteristics with regard to the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) rs3087243 genotypes.
| Parameter | All (n = 644) | rs3087243 | p-Value | |
|---|---|---|---|---|
| AA (n = 142) | GG/AG (n = 502) | |||
| Age (years) | 63 ± 15 | 67 ± 14 | 62 ± 15 | 0.0033 |
| Male (%) | 66 | 64 | 67 | 0.5560 |
| Body mass index | 28 ± 6 | 27 ± 6 | 28 ± 6 | 0.2881 |
| Sepsis severity | ||||
| Septic shock (%) | 51 | 52 | 51 | 0.8467 |
| SOFA score day 1 | 9.4 ± 3.9 | 9.4 ± 3.9 | 9.4 ± 3.9 | 0.8047 |
| APACHE II score day 1 | 22 ± 7 | 22 ± 7 | 21 ± 7 | 0.2844 |
| Comorbidities, n (%) | ||||
| Hypertension | 54 | 53 | 55 | 0.7094 |
| History of myocardial infarction | 5 | 6 | 5 | 0.9057 |
| Chronic obstructive pulmonary disease | 15 | 12 | 16 | 0.2436 |
| Renal dysfunction | 10 | 8 | 11 | 0.3879 |
| Non-insulin-dependent diabetes mellitus | 9 | 8 | 9 | 0.8492 |
| Insulin-dependent diabetes mellitus | 11 | 12 | 10 | 0.5349 |
| Chronic liver disease | 6 | 6 | 6 | 0.9875 |
| History of cancer | 16 | 15 | 16 | 0.7830 |
| History of stroke | 6 | 9 | 5 | 0.0623 |
| Recent surgical history, n (%) | ||||
| Elective surgery | 29 | 37 | 27 | |
| Emergency surgery | 53 | 46 | 55 | |
| No history of surgery | 18 | 17 | 18 | |
| Site of infection, n (%) | ||||
| Lung | 62 | 64 | 61 | |
| Abdomen | 20 | 20 | 20 | |
| Bone or soft tissue | 4 | 3 | 4 | |
| Surgical wound | 2 | 2 | 1 | |
| Urogenital | 2 | 1 | 3 | |
| Primary bacteremia | 7 | 6 | 7 | |
| Other | 3 | 4 | 4 | |
| Organ support (%) | ||||
| Used during observation period | ||||
| Mechanical ventilation | 93 | 96 | 93 | 0.1850 |
| Use of vasopressor | 79 | 82 | 78 | 0.4063 |
| Renal replacement therapy | 21 | 20 | 21 | 0.7173 |
| Used on sepsis onset | ||||
| Mechanical ventilation | 86 | 86 | 86 | 0.9381 |
| Use of vasopressor | 67 | 66 | 67 | 0.9048 |
| Renal replacement therapy | 9 | 9 | 9 | 0.8851 |
SOFA, sequential organ failure assessment; APACHE, acute physiology and chronic health evaluation.