Table 2.
Patient baseline characteristics with regard to the CTLA-4 haplotype H1: TAA.
| Parameter | All (n = 644) | H1: TAA | p-Value | |
|---|---|---|---|---|
| Positive (n = 447) | Negative (n = 197) | |||
| Age (years) | 63 ± 15 | 64 ± 15 | 62 ± 14 | 0.1014 |
| Male (%) | 66 | 67 | 64 | 0.4356 |
| Body mass index | 28 ± 6 | 28 ± 6 | 28 ± 7 | 0.2388 |
| Sepsis severity | ||||
| Septic shock (%) | 51 | 51 | 53 | 0.6384 |
| SOFA score day 1 | 9.4 ± 3.9 | 9.3 ± 3.9 | 9.7 ± 3.8 | 0.1802 |
| APACHE II score day 1 | 22 ± 7 | 21 ± 7 | 22 ± 7 | 0.1474 |
| Comorbidities, n (%) | ||||
| Hypertension | 54 | 54 | 54 | 0.9671 |
| History of myocardial infarction | 5 | 6 | 3 | 0.0758 |
| Chronic obstructive pulmonary disease | 15 | 15 | 16 | 0.5779 |
| Renal dysfunction | 10 | 10 | 11 | 0.6734 |
| Non-insulin-dependent diabetes mellitus | 9 | 9 | 8 | 0.6654 |
| Insulin-dependent diabetes mellitus | 11 | 9 | 13 | 0.1480 |
| Chronic liver disease | 6 | 6 | 8 | 0.3893 |
| History of cancer | 16 | 12 | 17 | 0.0731 |
| History of stroke | 6 | 6 | 6 | 0.8209 |
| Recent surgical history, n (%) | ||||
| Elective surgery | 29 | 31 | 26 | |
| Emergency surgery | 53 | 52 | 54 | |
| No history of surgery | 18 | 17 | 20 | |
| Site of infection, n (%) | ||||
| Lung | 62 | 64 | 58 | |
| Abdomen | 20 | 19 | 21 | |
| Bone or soft tissue | 4 | 3 | 6 | |
| Surgical wound | 2 | 2 | 2 | |
| Urogenital | 2 | 2 | 3 | |
| Primary bacteremia | 7 | 7 | 6 | |
| Other | 3 | 3 | 4 | |
| Organ support (%) | ||||
| Used during observation period | ||||
| Mechanical ventilation | 93 | 93 | 93 | 0.9580 |
| Use of vasopressor | 79 | 79 | 80 | 0.6749 |
| Renal replacement therapy | 21 | 18 | 26 | 0.0204 |
| Used on sepsis onset | ||||
| Mechanical ventilation | 86 | 86 | 85 | 0.8341 |
| Use of vasopressor | 67 | 66 | 69 | 0.4944 |
| Renal replacement therapy | 9 | 6 | 15 | 0.0005 |