Table 4.
Cox regression analysis with regard to the CTLA-4 rs3087243 genotypes.
| Variable | 90 Days | |||||
| Univariate Analysis | Multivariate Analysis | |||||
| Hazard Ratio | 95% CI | p-Value | Hazard Ratio | 95% CI | p-Value | |
| Age | 1.032 | 1.020–1.043 | 0.000000 | 1.025 | 1.013–1.038 | 0.000047 |
| Male gender | 1.093 | 0.810–1.474 | 0.558922 | 1.076 | 0.796–1.454 | 0.633436 |
| Body mass index | 0.985 | 0.961–1.009 | 0.218173 | 0.979 | 0.954–1.005 | 0.109574 |
| SOFA score day 1 | 1.104 | 1.065–1.143 | 0.000000 | 1.072 | 1.025–1.122 | 0.002432 |
| APACHE II score day 1 | 1.069 | 1.046–1.092 | 0.000000 | 1.033 | 1.004–.1062 | 0.026207 |
| Statin therapy | 1.114 | 0.807–1.536 | 0.511644 | 0.979 | 0.702–1.366 | 0.901706 |
| CTLA-4 rs3087243 G allele | 0.612 | 0.450–0.833 | 0.001760 | 0.667 | 0.489–0.909 | 0.010307 |
| 28 Days | ||||||
| Univariate Analysis | Multivariate Analysis | |||||
| Age | 1.029 | 1.015–1.043 | 0.000035 | 1.023 | 1.009–1.039 | 0.001824 |
| Male gender | 1.278 | 0.875–1.866 | 0.204154 | 1.270 | 0.868–1.860 | 0.218759 |
| Body mass index | 0.982 | 0.953–1.013 | 0.252686 | 0.976 | 0.945–1.008 | 0.135751 |
| SOFA score day 1 | 1.119 | 1.071–1.169 | 0.000000 | 1.085 | 1.026–1.146 | 0.003854 |
| APACHE II score day 1 | 1.073 | 1.045–1.102 | 0.000000 | 1.033 | 0.998–1.070 | 0.063787 |
| Statin therapy | 0.964 | 0.641–1.451 | 0.861906 | 0.841 | 0.552–1.281 | 0.420505 |
| CTLA-4 rs3087243 G allele | 0.624 | 0.428–0.908 | 0.013778 | 0.676 | 0.463–0.987 | 0.042323 |