Table 6.
Disease severity with regard to the CTLA-4 rs3087243 genotypes.
| Variable | All (n = 644) | rs3087243 | p-Value | |
|---|---|---|---|---|
| AA (n = 142) | GG/AG (n = 502) | |||
| SOFA | 7.0 ± 3.5 | 7.4 ± 3.8 | 6.9 ± 3.5 | 0.3005 |
| SOFA-Respiratory score | 2.0 ± 0.8 | 2.0 ± 0.8 | 2.0 ± 0.8 | 0.6043 |
| SOFA-Cardiovascular score | 1.5 ± 1.0 | 1.7 ± 1.0 | 1.5 ± 1.0 | 0.1284 |
| SOFA-Central Nervous System score | 2.0 ± 1.1 | 2.2 ± 1.0 | 1.9 ± 1.1 | 0.0094 |
| SOFA-Renal score | 0.8 ± 1.2 | 0.7 ± 1.1 | 0.8 ± 1.2 | 0.6669 |
| SOFA-Coagulation score | 0.4 ± 0.6 | 0.4 ± 0.7 | 0.3 ± 0.6 | 0.5521 |
| SOFA-Hepatic score | 0.4 ± 0.7 | 0.4 ± 0.7 | 0.4 ± 0.7 | 0.9780 |
| Organ support | ||||
| Ventilation days/observation days (%) | 66 ± 32 | 71 ± 32 | 65 ± 32 | 0.0280 |
| Vasopressor days/observation days (%) | 34 ± 30 | 37 ± 33 | 33 ± 29 | 0.2919 |
| Dialysis days/observation days (%) | 9 ± 23 | 9 ± 23 | 10 ± 22 | 0.8287 |
| Inflammatory values | ||||
| Leucocytes (1000/µL) | 13 ± 5 | 13 ± 5 | 13 ± 5 | 0.1026 |
| CRP (mg/L) | 152 ± 87 | 137 ± 81 | 156 ± 88 | 0.1356 |
| Procalcitonin (ng/dL) | 4.0 ± 9.3 | 3.5 ± 10.1 | 4.1 ± 9.1 | 0.0655 |
| Kidney values | ||||
| Urine output (mL/day) | 2978 ± 1337 | 2973 ± 1388 | 2979 ± 1324 | 0.9387 |
| Urine output (mL/kg/day) | 1.6 ± 0.8 | 1.6 ± 0.8 | 1.6 ± 0.78 | 0.9051 |
| Creatinine (mg/dL) | 1.2 ± 0.9 | 1.2 ± 0.9 | 1.3 ± 1.0 | 0.4218 |
| Liver values | ||||
| AST (GOT) (IU/L) | 169 ± 598 | 127 ± 238 | 182 ± 672 | 0.7476 |
| ALT (GPT) (IU/L) | 94 ± 188 | 101 ± 193 | 92 ± 187 | 0.2135 |
| Bilirubin (mg/dL) | 1.2 ± 2.1 | 1.2 ± 1.8 | 1.2 ± 2.1 | 0.5972 |
CRP, C-reactive protein; AST, aspartate transaminase; GOT, glutamic oxaloacetic transaminase; ALT, alanine transaminase; GPT, glutamate-pyruvate transaminase.