Table 7.
Disease severity with regard to the CTLA-4 haplotype H1: TAA.
| Variable | All (n = 644) | H1: TAA | p-Value | |
|---|---|---|---|---|
| Positive (n = 447) | Negative (n = 197) | |||
| SOFA | 7.0 ± 3.5 | 7.0 ± 3.6 | 7.1 ± 3.5 | 0.5088 |
| SOFA-Respiratory score | 2.0 ± 0.8 | 2.0 ± 0.8 | 1.9 ± 0.8 | 0.9796 |
| SOFA-Cardiovascular score | 1.5 ± 1.0 | 1.5 ± 1.0 | 1.5 ± 1.0 | 0.7476 |
| SOFA-Central Nervous System score | 2.0 ± 1.1 | 2.0 ± 1.1 | 1.9 ± 1.1 | 0.2731 |
| SOFA-Renal score | 0.8 ± 1.2 | 0.7 ± 1.1 | 0.9 ± 1.3 | 0.1230 |
| SOFA-Coagulation score | 0.4 ± 0.6 | 0.4 ± 0.6 | 0.3 ± 0.6 | 0.6741 |
| SOFA-Hepatic score | 0.4 ± 0.7 | 0.4 ± 0.7 | 0.4 ± 0.8 | 0.4264 |
| Organ support | ||||
| Ventilation days/observation days (%) | 66 ± 32 | 67 ± 32 | 65 ± 32 | 0.3607 |
| Vasopressor days/observation days (%) | 34 ± 30 | 33 ± 30 | 35 ± 30 | 0.6474 |
| Dialysis days/observation days (%) | 9 ± 23 | 9 ± 22 | 11 ± 23 | 0.1246 |
| Inflammatory values | ||||
| Leucocytes (1000/µL) | 13 ± 5 | 13 ± 5 | 13 ± 4 | 0.4087 |
| CRP (mg/L) | 152 ± 87 | 147 ± 81 | 162 ± 99 | 0.4562 |
| Procalcitonin (ng/dL) | 4.0 ± 9.3 | 3.5 ± 9.1 | 5.1 ± 9.7 | 0.0002 |
| Kidney values | ||||
| Urine output (mL/day) | 2978 ± 1337 | 3060 ± 1370 | 2792 ± 1242 | 0.0229 |
| Urine output (mL/kg/day) | 1.6 ± 0.8 | 1.6 ± 0.8 | 1.5 ± 0.8 | 0.0529 |
| Creatinine (mg/dL) | 1.2 ± 0.9 | 1.2 ± 0.9 | 1.4 ± 1.1 | 0.0902 |
| Liver values | ||||
| AST (GOT) (IU/L) | 169 ± 598 | 184 ± 687 | 131 ± 272 | 0.9910 |
| ALT (GPT) (IU/L) | 94 ± 188 | 99 ± 206 | 81 ± 142 | 0.1307 |
| Bilirubin (mg/dL) | 1.2 ± 2.1 | 1.2 ± 1.8 | 1.3 ± 2.5 | 0.9584 |