Table 3.
Cross sectional association between thyroid function tests and NYHA class
| Entire Population n=1365 |
Excluding amiodarone and levothyroxine users n=1070 |
Restricting to euthyroid range excluding amiodarone and levothyroxine users n=973 |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NYHA Class | NYHA Class | NYHA Class | |||||||||||||
| I n=227 |
II n=614 |
III n=433 |
IV n=82 |
p-value | I n=200 |
II n=495 |
III n=318 |
IV n=52 |
p-value | I n=182 |
II n=453 |
III n=288 |
IV n=46 |
p-value | |
| TSH mIU/L | 1.62 (1.5) |
1.82 (2.24) |
2.2 (5.0) |
3.11 (5.56) |
<0.001 | 1.54 (1.32) |
1.65 (2.04) |
1.71 (1.18) |
2.26 (1.40) |
<0.001 | 1.46 (0.77) |
1.51 (0.79) |
1.58 (0.78) |
2.15 (0.98) |
<0.001 |
| FT4 ng/dL | 1.08 (0.16) |
1.11 (0.18) |
1.15 (0.22) |
1.20 (0.25) |
<0.001 | 1.06 (0.13) |
1.07 (0.14) |
1.11 (0.19) |
1.15 (0.17) |
<0.001 | 1.06 (0.12) |
1.07 (0.14) |
1.1 (0.16) |
1.17 (0.15) |
<0.001 |
| TT3 ng/dL | 104.2 (18.8) |
100.9(20.8) | 95.7 (23.4) |
87.9 (26.0) |
<0.001 | 105.5(18.2) | 103.5 (19.5) |
99.6 (22.1) |
95.1 (26.6) |
<0.001 | 105.5 (18.2) |
104.2 (19.5) |
99.6 (20.2) |
96.4 (20.2) |
<0.001 |
Data are presented as mean (SD).
NYHA, New York Heart Association; TSH, thyroid stimulating hormone; FT4, free thyroxine; TT3, total triiodothyronine
One-way ANOVA was performed using log transformed values of each thyroid function test in separate models. See Supplement Table 1 for results of adjusted multinomial logistic regression analyses