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. Author manuscript; available in PMC: 2019 Jul 21.
Published in final edited form as: Nat Immunol. 2019 Jan 21;20(2):129–140. doi: 10.1038/s41590-018-0288-7

Figure 7. Adoptive transfer of CD49b+ spleen cells from control littermates enhances bacterial clearance in Basoph8 x Tnffl/fl mice.

Figure 7.

Tnffl/fl and Basoph8 x Tnffl/fl mice received an adoptive transfer at 3 h after CLP with the CD49b+ basophil-enriched fraction of splenocytes (4 × 105 cells) obtained from Tnffl/fl mice or Basoph8 x Tnffl/fl mice. (a-d) Concentrations of TNF (a) and IL-6 (c), colony forming units (CFU) (b) and numbers of basophils (FcεRIα+ CD49b+ c-Kit− cells) (d) in the peritoneal cavity at 24 h after CLP. Data in a–d are shown as means + SEM with squares and circles representing values for individual mice (n = 4 in a–c and n = 3 in d for Tnffl/fl + CD49b+ spleen cells from Tnffl/fl; n = 5 in a–c and n = 3 in d for Tnffl/fl + CD49b+ spleen cells from Basoph8 x Tnffl/fl; n = 7 in a and c, n = 6 in b and n = 5 in d for Basoph8 x Tnffl/fl + CD49b+ spleen cells from Tnffl/fl; and n = 4 in a, n = 6 in b, n = 7 in c and d for Basoph8 x Tnffl/fl + CD49b+ spleen cells from Basoph8 x Tnffl/fl). Data were pooled from the n = 3 independent experiments performed, each of which gave similar results. P values by Mann-Whitney test.