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. 2019 Jan 29;20:20. doi: 10.1186/s12931-019-0983-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Lung adenoma and squamous cell carcinoma in WT mice and NLRP3−/− mice induced by B(a)p or B(a)p plus LPS. A Representative images of normal lung tissue (a) and tumor (b) by transmission electron microscopy in WT mice. B Representative images of lung adenoma (a) and squamous cell carcinoma (b) with amplification (200×). C The percentage of lung adenoma and squamous cell carcinoma induced by B(a)p or B(a)p plus LPS in WT mice and NLRP3−/− mice. Red arrows show heterochromatin in lung tumors induced by B(a)p plus LPS. *: vs B(a)p-WT, P < 0.05; #: vs B(a)p plus LPS-WT, P < 0.05; ∆: vs B(a)p-NLRP3−/−, P < 0.05, ♦: vs B(a)p plus LPS-NLRP3−/−, P < 0.05