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. 2018 Dec 1;78(2):270–277. doi: 10.1136/annrheumdis-2018-213882

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0

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OA miRNA–mRNA interactome. Network of differentially expressed miRNAs targeting differentially expressed genes between unaffected (preserved) and lesioned OA cartilage. Diamonds are miRNAs and circles genes; edges denote that an miRNA targets the connected gene. The size of the nodes is proportional to the number of edges (interactions). Node colour characterises the strength and the direction of the expression change between unaffected (preserved) and lesioned OA cartilage. Edge thickness corresponds to Pearson’s correlation between the miRNA and gene across all samples. miRNA, microRNA; mRNA, messenger RNA; OA, osteoarthritis.