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. 2018 Nov 20;78(2):228–237. doi: 10.1136/annrheumdis-2018-213523

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Single-dose pharmacokinetic and exploratory pharmacodynamic study of VIB9600 in cynomolgus monkeys. Male monkeys were given VIB9600 once at 1, 10 or 100 mg/kg in a volume of 2 mL/kg via intravenous injection. (A) Serum concentration of VIB9600 in cynomolgus monkeys at various time points after a single dose was determined by ELISA. (B) and (C) FcγRIIA levels on monocytes and neutrophils were determined at different time points by flow cytometry. The FcγRIIA levels (average percentage) relative to the mean predose levels are shown.