Table 5.

Multivariate Analyses of Detailed Country Comparisons of Therapeutic Options

(A) Comparison of binary response options LT4 vs. any T3-containing therapy
Country of practice	Adjusted OR	CI	p-Value
North America vs. others	1.8	1.3–2.4	0.0001
South America vs. others	0.38	0.2–0.68	0.0010
Europe vs. others	0.62	0.4–0.9	0.014
Asia vs. others	0.86	0.48–1.5	0.61
North American vs. South America	2.9	1.7–5.2	0.0002
North America vs. Europe	1.8	1.2–2.7	0.0027
North America vs. Asia	1.4	0.8–2.6	0.23

(B) Comparison of grouped response optionsa
Country of practice	Treatment options	OR	CI	p-Value
North America vs. others	1 vs. 2	0.92	0.68–1.3	0.59
North America vs. others	1 vs. 3	1.9	1.2–2.9	0.0056
North America vs. others	1 vs. 4	1.70	1.0–2.9	0.0444
South America vs. others	1 vs. 2	0.47	0.26–0.85	0.012
South America vs. others	1 vs. 3	0.17	0.07–0.43	0.0002
South America vs. others	1 vs. 4	0.39	0.14–1.1	0.069
Europe vs. others	1 vs. 2	1.34	0.92–1.9	0.12
Europe vs. others	1 vs. 3	0.81	0.47–1.4	0.45
Europe vs. others	1 vs. 4	0.54	0.28–1.0	0.065
Asia vs. others	1 vs. 2	0.73	0.41–1.3	0.29
Asia vs. others	1 vs. 3	0.74	0.3–1.7	0.47
Asia vs. others	1 vs. 4	0.88	0.4–2.3	0.80
North American vs. South America	1 vs. 2	1.9	1.1–3.5	0.027
North American vs. South America	1 vs. 3	6.4	2.5–16.0	<0.0001
North American vs. South America	1 vs. 4	2.9	1.0–8.1	0.043
North America vs. Europe	1 vs. 2	0.76	0.5–1.1	0.16
North America vs. Europe	1 vs. 3	1.5	0.8–2.6	0.17
North America vs. Europe	1 vs. 4	2.1	1.03–4.0	0.042
North America vs. Asia	1 vs. 2	1.3	0.69–2.2	0.46
North America vs. Asia	1 vs. 3	1.7	0.72–3.8	0.23
North America vs. Asia	1 vs. 4	1.4	0.5–3.6	0.51

Controlling for all physician characteristics (number of years in practice, country of practice, and specialty). Significant comparisons are indicated in bold.

^aContinuing LT4 = therapeutic option 1 (reference), increasing LT4 = therapeutic option 2; adding LT3 to same or reduced LT4 = option 3; replacing LT4 with DTE or LT3 = option 4.