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. 2019 Jan 3;12:76–86. doi: 10.1016/j.isci.2018.12.030

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Relative Positions of NTD and NTE of IF3_mt and Initiator tRNA

(A) The core of NTD (red) of IF3_mt is situated away from the anticodon stem of the initiator tRNA (light blue) (M.R.S., R.K.K., N.K. Banavali, M.E.H., L.L.S., and R.K.A., unpublished data; Kummer et al., 2018) to interact with the conserved 3GC base pairs (dark blue) in the initiator tRNA. The mRNA (pink) is also shown. IF3_mt domains are colored as in Figure 1.

(B) The NTD of IF3_mt interacts with h24 (green) of 12S rRNA through its NTE (purple), whereas the h24 contacts the 3GC base pairs of the initiator tRNA with the help of a conserved adenine (A424). The cryo-EM density corresponding to the NTE (gray mesh) is also shown. Thumbnails to the left represent overlaid positions of the ligands relative to the overall orientation to the 28S subunit (yellow). Landmarks on the thumbnail: h, head; b, body; pt, platform.