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. 2019 Jan 7;12:87–101. doi: 10.1016/j.isci.2019.01.005

Figure 7.

Figure 7

Zfp238 Regulates Ucp1 Expression by Inhibiting Foxo1

(A) Representative western blot of Zfp238 and Foxo1 in differentiated 3T3-L1 cells infected with retroviruses encoding pSINsi-DK II-Zfp238, pSINsi-DK II-SCR, pSINsi-DK II-Foxo1, or double knockdown (DKO) of Zfp238 and Foxo1.

(B and C) Effects of double knockdown of Zfp238 and Foxo1 in differentiated 3T3-L1 cells on Ucp1 expression induced by 31°C (B) or FSK (C). Experiments were performed three times. Data represent the ratio of gene expression level in 3T3-L1 cells at each basal state and means ± SEM. *p < 0.05 by one-way ANOVA.