Table 1.
Number of intact pyramidal cells and dendritic spines from secondary and tertiary apical dendrites in the hippocampal CA1 region, and levels of MDA, SOD, and GSH-Px in different groups
| AD | T | F | F + T | |
|---|---|---|---|---|
| Number of intact pyramidal cells (Nissl) | 38.3±5.75 | 74.6±9.30* | 41.43±6.10 | 53.2±8.15 |
| Number of dendritic spines (Golgi) | 1.35±0.18 | 2.04±0.26* | 1.41±0.21 | 1.62±0.22 |
| SOD (IU/mL) | 175.36±13.45 | 230.22±20.06* | 181.70±16.43 | 194.06±15.28 |
| MDA (nM) | 3.10±0.39 | 1.92±0.32* | 3.09±0.41 | 2.89±0.30 |
| GSH-Px (nM) | 35.06±3.95 | 53.64±5.28* | 38.85±3.82 | 40.16±4.05 |
Data are expressed as the mean ± SD (n = 10; one-way analysis of variance followed by the least significant difference post hoc test). *P < 0.05, vs. AD group. AD: AD group; T: testosterone group; F: flutamide group; F + T: flutamide + testosterone group. AD: Alzheimer’s disease; SOD: superoxide dismutase; MDA: malondialdehyde; GSH-Px: glutathione peroxidase.