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. 2018 Sep 25;3(4):28. doi: 10.3390/biomimetics3040028

Figure 2.

Figure 2

Half maximal inhibitory concentration (IC50) of SN38 and combination therapy effect. (a) Cell viability assay in Mel 202 cells treated with SN38 at different concentrations. The IC50 in which the cell viability is reduced 50% is 100 nM for Mel 202 cells (*** p < 0.001). (b) Cell viability assay in Mel 202 cells treated with SN38, DNA mix 1 and siRNA mix. The cell viability is reduced by 50% at a very low concentration of SN38 in the combination conditions (*** p < 0.001). Statistical analysis was performed using one-way ANOVA (each group vs. control).