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Synthesis of the modified SN38 (2) with the linker for the conjugation with AuNPs. Lipoic acid was activated (1) and incubated with SN38 to yield the desired product (2). DCC: N,N’-dicyclohexylcarbodimide; DIPEA: N,N-diisopropylethylamine; DMAP: 4-Dimethylaminopyridine; DMF: Dimethylformamide; NHS: N-hydroxysuccinimide; RT: Room temperature; THF: Tetrahydrofuran.
