Table 6.
Predictors of surgical margin status.
| Characteristic | Positive Margins | Multivariate Analysis of Kadish | Multivariate Analysis of AJCC | ||
|---|---|---|---|---|---|
| No./Total Patients (%) | P-Value | P-Value | |||
| Overall | 107/380 (28.2%) | ||||
| Sex | P = 0.91 | ||||
| Male | 64/229 (28.0%) | NI | NI | NI | NI |
| Female | 43/151 (28.5%) | NI | NI | NI | NI |
| Age at Diagnosis | P = 0.77 | ||||
| <50 yrs | 43/141 (30.5%) | NI | NI | NI | NI |
| 50–64 yrs | 41/155 (26.5%) | NI | NI | NI | NI |
| 65–79 yrs | 19/73 (26.0%) | NI | NI | NI | NI |
| 80 yrs or more | 4/11 (36.4%) | NI | NI | NI | NI |
| Race | P = 0.081 | ||||
| White | 95/330 (28.8%) | NI | NI | NI | NI |
| Black | 7/16 (43.8%) | NI | NI | NI | NI |
| Other | 5/34 (14.7%) | NI | NI | NI | NI |
| Insurance | P = 0.36 | ||||
| Private | 77/268 (28.7%) | NI | NI | NI | NI |
| Uninsured | 1/12 (8.3%) | NI | NI | NI | NI |
| Government | 28/93 (30.1%) | NI | NI | NI | NI |
| Unknown | 1/7 (14.3%) | NI | NI | NI | NI |
| Hospital Type | P = 0.46 | ||||
| Academic/NCI CC | 64/250 (25.6%) | Ref | Ref | Ref | Ref |
| Community | 3/11 (28.3%) | 1.57 (0.36–6.89) | P = 0.55 | 1.68 (0.37–7.52) | P = 0.50 |
| Comp. Community | 21/63 (33.3%) | 2.10 (1.04–4.27) | P = 0.039 | 2.16 (1.05–4.41) | P = 0.035 |
| Other/Unknown | 19/56 (28.2%) | 1.34 (0.69–2.58) | P = 0.39 | 1.46 (0.75–2.83) | P = 0.27 |
| Hospital Volume | P = 0.56 | ||||
| Low: 1–2 | 20/114 (26.3%) | Ref | Ref | Ref | Ref |
| Medium: 3–10 | 44/140 (31.4%) | 1.21 (0.65–2.25) | P = 0.55 | 1.28 (0.68–2.40) | P = 0.44 |
| High: >10 | 33/126 (26.2%) | 1.08 (0.55–2.15) | P = 0.82 | 1.08 (0.54–2.19) | P = 0.83 |
| Charles-Deyo Cormibidity Score | P = 0.77 | ||||
| 0 | 90/330 (27.3%) | NI | NI | NI | NI |
| 1 | 15/43 (34.9%) | NI | NI | NI | NI |
| 2 | 1/4 (25.0%) | NI | NI | NI | NI |
| 3 | 1/3 (33.3%) | NI | NI | NI | NI |
| Kadish | P < 0.0001 | ||||
| A | 13/92 (14.1%) | Ref | Ref | NI | NI |
| B | 12/56 (21.4%) | 1.52 (0.63–3.67) | P = 0.35 | NI | NI |
| C | 65/200 (32.5%) | 3.09 (1.57–6.08) | P = 0.001 | NI | NI |
| D | 17/32 (53.1%) | 8.39 (3.20–22.0) | P < 0.0001 | NI | NI |
| T-Stage | P < 0.0001 | ||||
| 1 | 13/91 (14.3%) | NI | NI | Ref | Ref |
| 2 | 7/42 (16.7%) | NI | NI | 1.30 (0.47–3.59) | P = 0.062 |
| 3 | 27/98 (27.6%) | NI | NI | 2.22 (1.03–4.77) | P = 0.041 |
| 4a | 16/44 (36.4%) | NI | NI | 3.56 (1.46–8.69) | P = 0.005 |
| 4b | 44/105 (41.9%) | NI | NI | 4.70 (2.25–9.81) | P < 0.0001 |
| Dulguerov T- Stage | P<0.0001 | ||||
| 1 | 25/150 (16.7%) | NI | NI | NI | NI |
| 2 | 23/83 (27.7%) | NI | NI | NI | NI |
| 3 | 16/56 (28.6%) | NI | NI | NI | NI |
| 4 | 43/91 (47.3%) | NI | NI | NI | NI |
| Lymph Node Status | P = 0.003 | ||||
| (+) Lymph Nodes | 13/24 (54.2%) | NI | NI | Ref | Ref |
| (−) Lymph Nodes | 94/356 (26.4%) | NI | NI | 0.32 (0.13–0.78) | P = 0.012 |
| Distant Metastasis | P = 0.17 | ||||
| (+) Metastases | 4/8 (50.0%) | NI | NI | NI | NI |
| (−) Metastases | 103/372 (28.2%) | NI | NI | NI | NI |
| Hyams Grade | P = 0.61 | ||||
| 1 | 9/27 (33.3%) | Ref | Ref | Ref | Ref |
| 2 | 23/74 (31.1%) | 0.83 (0.31–2.22) | P = 0.71 | 0.82 (0.30–2.23) | P = 0.70 |
| 3 | 22/67 (32.8%) | 0.88 (0.32–2.38) | P = 0.80 | 0.81 (0.29–2.22) | P = 0.68 |
| 4 | 6/20 (30.0%) | 0.62 (0.16–2.40) | P = 0.49 | 0.57 (0.15–2.21) | P = 0.42 |
| Not stated | 47/192 (24.5%) | 0.55 (0.22–1.39) | P = 0.21 | 0.53 (0.21–1.33) | P = 0.18 |
Abbreviations: CI, confidence interval; ENB, Esthesioneuroblastoma; NCI, National Cancer Institute; NI, not included; Ref, reference.