Figure 1.

Workflow of mtDNA ATAC-Seq Data Analysis

(A) Human mtDNA map. Light blue panels represent rRNA. Orange panels represent protein-coding genes. Gray panels represent tRNA genes. Green panel represent the D loop. Blue boxes represent the three conserved sequence blocks (CSBs). The dashed box highlights the D loop and known mtDNA promotors.

(B) Workflow describing the identification of mtDNA ATAC-seq footprinting (ASFP) sites. Available ATAC-seq data from mouse embryos were downloaded from the Gene Expression Omnibus (GEO) database (see Transparent Methods). ATAC-seq reads were mapped onto the mouse mtDNA sequence, and read coverage per base was calculated.