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. 2018 Sep 18;7(2):255–274. doi: 10.1016/j.jcmgh.2018.09.006

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

IL22 inhibits wnt signaling in vitro and in vivo. (A–C) Relative mRNA expression of Wnt3, Lrp5, Lrp6, Dkk1, Dkk2, Fzd7, Axin2, C-myc, and Cd44 in jejunal enteroids cultured without (blue symbols) or with IL22 (black symbols) (5 ng/mL, PeproTech) in ENR for 3 days. n = 6 in the representative experiments shown. *P < .05; **P < .01. (D) Quantitative RT-PCR of Dkk1, Axin2, and Cmyc mRNA expression in isolated jejunal epithelium. n = 3–7 in the representative experiment shown. *P < .05. (E) Immunostains and quantitative analysis of beta-catenin labeling in small intestine from untreated or IL22-treated mice. n = 12 fields from 5 mice. Bar, 100 μm.