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MIR22HG negatively regulated NOTCH2 signaling. Upregulation of MIR22HG markedly decreased HES6 and HEY1 mRNA relative expression in AGS (A) and MKN-45 (B) cells. Downregulation of MIR22HG dramatically increased HES6 and HEY1 mRNA relative expression in AGS (C) and MKN-45 (D) cells. (E) Silencing of MIR22HG elevated HEY1 and nucleus NOTCH2 proteins expression in AGS and MKN-45 cells. * P<0.05.
