Table 1.

Impact of PROMs in glaucoma RCTs, highlighting only trials in which PROMs were selected as primary outcome measures

Study name	N	Intervention	PRO outcome measures	Impact	Reference
Tube Versus Trabeculectomy Study	202 patients with previous trabeculectomy and/or cataract surgery	Tube shunt (350 mm2 Baerveldt implant) vs trabeculectomy with MMC	NEI-VFQ composite score and minimally important difference	No significant difference at baseline or annual review for 5 years	Kotecha et al110
Glaucoma Australia Educational Impact	101 newly diagnosed glaucoma patients	Glaucoma education vs control	Auckland Glaucoma Knowledge Questionnaire	Significant reduction in anxiety in intervention group	Skalicky et al111
Glaucoma Intensive Treatment Study	242 glaucoma patients	Topical drug monotherapy vs topical triple therapy plus 360 degree laser trabeculoplasty	Eye-tem Bank Glaucoma module	Study Protocol Published	Lamoureux et al7 Bengtsson et al112
Treatment of Advanced Glaucoma Study	440 patients presenting with advanced open angle glaucoma	Medical therapy vs augmented trabeculectomy	NEI-VFQ at 24 m. EQ-5D-5L, HUI-3 and Glaucoma Utility Index	Study protocol published	King et al51
Shared Care for Stable Glaucoma Patients	233 patients with stable glaucoma	Primary eye care vs specialist outpatient clinic	Patient satisfaction, cost	Comparable patient satisfaction, clinical care and management, but lower cost with PEC	Goh et al113
Laser in Glaucoma and OHT Trial	718 patients with glaucoma or OHT	Selective laser trabeculoplasty vs topical treatment	EQ-5D-5L, Glaucoma Utility Index, GSS, Glaucoma QoL	Study protocol	Gazzard et al8

Abbreviations: EDSQ, Eye Drop Satisfaction Questionnaire; GSS, Glaucoma Symptom Scale; HADS, Hospital Anxiety and Depression Scale; OHT, ocular hypertension; QoL, quality of life; MMC, mitomycin C; PRO, patient-related outcome; NEI-VFQ, National Eye Institute-Vision Function Questionnaire ; RCT, randomized controlled clinical trial; GITS, Glaucoma Intensive Treatment Study.