Table 1.
Study name | N | Intervention | PRO outcome measures | Impact | Reference |
---|---|---|---|---|---|
Tube Versus Trabeculectomy Study | 202 patients with previous trabeculectomy and/or cataract surgery | Tube shunt (350 mm2 Baerveldt implant) vs trabeculectomy with MMC | NEI-VFQ composite score and minimally important difference | No significant difference at baseline or annual review for 5 years | Kotecha et al110 |
Glaucoma Australia Educational Impact | 101 newly diagnosed glaucoma patients | Glaucoma education vs control | Auckland Glaucoma Knowledge Questionnaire | Significant reduction in anxiety in intervention group | Skalicky et al111 |
Glaucoma Intensive Treatment Study | 242 glaucoma patients | Topical drug monotherapy vs topical triple therapy plus 360 degree laser trabeculoplasty | Eye-tem Bank Glaucoma module | Study Protocol Published | Lamoureux et al7 Bengtsson et al112 |
Treatment of Advanced Glaucoma Study | 440 patients presenting with advanced open angle glaucoma | Medical therapy vs augmented trabeculectomy | NEI-VFQ at 24 m. EQ-5D-5L, HUI-3 and Glaucoma Utility Index | Study protocol published | King et al51 |
Shared Care for Stable Glaucoma Patients | 233 patients with stable glaucoma | Primary eye care vs specialist outpatient clinic | Patient satisfaction, cost | Comparable patient satisfaction, clinical care and management, but lower cost with PEC | Goh et al113 |
Laser in Glaucoma and OHT Trial | 718 patients with glaucoma or OHT | Selective laser trabeculoplasty vs topical treatment | EQ-5D-5L, Glaucoma Utility Index, GSS, Glaucoma QoL | Study protocol | Gazzard et al8 |
Abbreviations: EDSQ, Eye Drop Satisfaction Questionnaire; GSS, Glaucoma Symptom Scale; HADS, Hospital Anxiety and Depression Scale; OHT, ocular hypertension; QoL, quality of life; MMC, mitomycin C; PRO, patient-related outcome; NEI-VFQ, National Eye Institute-Vision Function Questionnaire ; RCT, randomized controlled clinical trial; GITS, Glaucoma Intensive Treatment Study.