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. Author manuscript; available in PMC: 2019 Jan 30.

Published in final edited form as: J Alzheimers Dis. 2019;67(2):757–768. doi: 10.3233/JAD-170578

Figure 1. — IADL vs. entorhinal cortex tau burden by amyloid status in MCI participants (A) and in AD dementia participants (B). Greater IADL impairment (higher FAQ score) is associated with greater entorhinal cortex tau burden among PiB-positive participants but not among PiB-negative participants (for both MCI and AD dementia participants). The unadjusted Pearson correlations are shown in the graphs. In the linear regression model adjusted for age, sex, and MMSE, an interaction between tau and amyloid was significant when related to IADL (partial r=0.51, p=0.004). AD (Alzheimer’s disease), FAQ (Functional Activities Questionnaire), FTP (flortaucipir), IADL (instrumental activities of daily living), MCI (mild cognitive impairment), MMSE (Mini-Mental State Exam), PiB (Pittsburgh Compound B), SUVR (standardized uptake value ratio).

Figure 1. — IADL vs. entorhinal cortex tau burden by amyloid status in MCI participants (A) and in AD dementia participants (B). Greater IADL impairment (higher FAQ score) is associated with greater entorhinal cortex tau burden among PiB-positive participants but not among PiB-negative participants (for both MCI and AD dementia participants). The unadjusted Pearson correlations are shown in the graphs. In the linear regression model adjusted for age, sex, and MMSE, an interaction between tau and amyloid was significant when related to IADL (partial r=0.51, p=0.004). AD (Alzheimer’s disease), FAQ (Functional Activities Questionnaire), FTP (flortaucipir), IADL (instrumental activities of daily living), MCI (mild cognitive impairment), MMSE (Mini-Mental State Exam), PiB (Pittsburgh Compound B), SUVR (standardized uptake value ratio).