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. Author manuscript; available in PMC: 2019 Jan 30.

Published in final edited form as: J Alzheimers Dis. 2019;67(2):757–768. doi: 10.3233/JAD-170578

Figure 3. — Whole brain FTP PET SUVR T-statistics maps showing the unadjusted association between IADL (FAQ) and tau burden (FTP PET SUVR) in all participants (A), the association adjusted for age, sex, and MMSE (global cognition) (B), and in participants with greater amyloid burden (PiB-positive), the association adjusted for age, sex, and MMSE (C). An additional map for PiB-positive participants adjusted for age, sex, and education with a threshold of p<0.001 is shown (D). Threshold on the first 3 maps was set at T>2.65, p<0.01 in order to show a wider range of results. For t=2.0, p=0.05; t=2.65, p=0.01; t=3.0, p=0.005; t=3.57, p=0.001; t=4.0, p=0.0003; t=4.9, p=0.00002. FAQ (Functional Activities Questionnaire), FTP (flortaucipir), IADL (instrumental activities of daily living), MMSE (Mini-Mental State Exam), PET (positron emission tomography), PiB (Pittsburgh Compound B), SUVR (standardized uptake value ratio).

Figure 3. — Whole brain FTP PET SUVR T-statistics maps showing the unadjusted association between IADL (FAQ) and tau burden (FTP PET SUVR) in all participants (A), the association adjusted for age, sex, and MMSE (global cognition) (B), and in participants with greater amyloid burden (PiB-positive), the association adjusted for age, sex, and MMSE (C). An additional map for PiB-positive participants adjusted for age, sex, and education with a threshold of p<0.001 is shown (D). Threshold on the first 3 maps was set at T>2.65, p<0.01 in order to show a wider range of results. For t=2.0, p=0.05; t=2.65, p=0.01; t=3.0, p=0.005; t=3.57, p=0.001; t=4.0, p=0.0003; t=4.9, p=0.00002. FAQ (Functional Activities Questionnaire), FTP (flortaucipir), IADL (instrumental activities of daily living), MMSE (Mini-Mental State Exam), PET (positron emission tomography), PiB (Pittsburgh Compound B), SUVR (standardized uptake value ratio).