Table 3. MDD PRS association analyses.
Basic model has age, sex and 4 MDS components to control for population stratification and PRS as fixed effects. Family structure was controlled for using a pedigree matrix in AS-Reml. Depression was added as fixed effects in subsequent models. Best threshold PRS for each trait used, for MDD p ≤ 0.5, SLEs p ≤ 0.35 and Neuroticism p ≤ 0.23.
| MDD | SLEs | Dependent SLEs | Indep SLEs | Neuroticism | |
|---|---|---|---|---|---|
| Basic Model | β=0.113
(0.028), r 2=0.17%, p=3.7 × 10 -4 |
β=0.053
(0.011), r 2=0.28%, p=3.0 × 10 -6 |
β=0.058
(0.011), r 2=0.33%, p=13.5 × 10 -7 |
β=0.037
(0.011), r 2=0.14%, p=1.2 × 10 -3 |
β=0.080
(0.012), r 2=0.61%, p=1.4 × 10 -11 |
| Control for Dep | - | β=0.044
(0.011), r 2=0.19%, p=1.3 × 10 -4 |
β=0.046
(0.011), r 2=0.21%, p=4.9 × 10 -5 |
β=0.031
(0.011), r 2=0.09%, p=8.2 × 10 -3 |
β=0.065
(0.012), r 2=0.41%, p=2.9 × 10 -8 |
| Control for GHQ | - | β=0.035
(0.011), r 2=0.12%, p=1.9 × 10 -3 |
β=0.041
(0.011), r 2=0.17%, p=1.6 × 10 -4 |
β=0.022
(0.011), r 2=0.05%, p=5.2 × 10 -2 |
β=0.056
(0.011), r 2=0.30%, p=8.3 × 10 -7 |