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. 2019 Jan 14;3:11. Originally published 2018 Feb 14. [Version 2] doi: 10.12688/wellcomeopenres.13893.2

Table 4. Neuroticism PRS association analyses.

Basic model has age, sex and 4 MDS components to control for population stratification and PRS as fixed effects. Family structure was controlled for using a pedigree matrix in AS-Reml. Neuroticism was added as a fixed effect in subsequent model. Best threshold PRS for each trait used, for MDD p ≤ 0.10 and SLEs/Neuroticism p ≤ 0.60.

MDD SLEs Dependent SLEs Indep SLEs Neuroticism
Basic Model β=0.120
(0.028),
r 2=0.20%,
p=5.4 × 10 -5 		β=0.022
(0.011),
r 2=0.05%,
p=0.04		 β=0.016
(0.011),
r 2=0.03%,
p=0.14		 β=0.016
(0.011),
r 2=0.03%,
p=0.14		 β=0.12
(0.011),
r 2=1.4%,
p=8.2 × 10 -27
Control for Neurot β=0.051
(0.029),
r 2=0.03%,
p=0.11		 β=0.01
(0.011),
r 2=0.01%,
p=0.32		 β=0.004
(0.011),
r 2=0.00%,
p=0.72		 β=0.009
(0.011),
r 2=0.00%,
p=0.45		 -