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. 2019 Jan 28;26(1):12–22. doi: 10.1080/10717544.2018.1507057

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — In vivo antitumor performance of low-dose X-NP-DOX in MCF-7 mouse orthotopic tumor-bearing model. The nude mouse orthotopic model was established to investigate the effect of low-dose X-NP-DOX on tumor growth. Tissues of orthotopic tumors, liver, lung, heart, and kidney were collected at day 29 and analyzed by H&E or TUNEL staining (magnification, 400×). (A) The results showed that tumor growth was effectively inhibited by X-NP-DOX, whereas continuous tumor growth was observed in mice treated with free DOX (F = 12.25, p = .0010). (B,C) The histological analysis using H&E staining revealed that X-NP-DOX caused widespread necrosis in the tumor tissue with no damage to the liver, kidney, spleen, and heart, and the malignant tumor cells obviously infiltrated and invaded the surrounding tissue in free DOX treatment or saline group. (D) TUNEL-positive staining of tumors in mice treated with X-NP-DOX was significant higher compared with tumors from mice treated with free DOX (p < .05).