Figure 3.

Formation of superhelical supramolecular assemblies of a single heptad repeat with phenylalanines as interacting moieties stabilized by the incorporation of Aib, an α-methylated residue. The process of molecular self-assembly leads to the formation of ordered assemblies as observed using electron microscopy (scale bar is 100 nm). X-ray crystallography shows the organization into helical assemblies with the hydrophobic phenylalanines serving as interfaces between the helical elements. Modified from Reference 154 following author reuse guidelines.