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. 2019 Jan 15;199(2):181–189. doi: 10.1164/rccm.201804-0678OC

Figure 3.

Figure 3.

Prognostication of mortality or severe morbidity in pediatric acute respiratory distress syndrome. In the combined cohorts, logistic regression for the composite outcome of mortality or severe morbidity was performed with the Day 1 PaO2/FiO2 (P/F) ratio and then again with both the Day 1 P/F ratio and Day 1 plasma MMP (matrix metalloproteinase) profile. The model using both Day 1 P/F ratio and the Day 1 plasma MMP profile demonstrated greater area under the receiver operating characteristic curve (AUROC) than the model using Day 1 P/F ratio alone (AUROC, 0.75; 95% confidence interval [CI], 0.68–0.82 vs. AUROC, 0.66; 95% CI, 0.58–0.73; P = 0.009). Similar findings occurred when replacing the P/F ratio with the oxygenation index (AUROC, 0.78; 95% CI, 0.71–0.85 vs. AUROC, 0.69; 95% CI, 0.62–0.77; P = 0.019). OI = oxygenation index.