Comparison 12. Deaths.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Deaths ‐ overall	52	216246	Odds Ratio (M‐H, Random, 95% CI)	0.96 [0.87, 1.06]
2 Deaths ‐ subgroup analysis by type of macrolide	52	216246	Odds Ratio (M‐H, Random, 95% CI)	0.96 [0.87, 1.06]
2.1 Azithromycin	24	204719	Odds Ratio (M‐H, Random, 95% CI)	0.97 [0.85, 1.10]
2.2 Clarithromycin	8	7216	Odds Ratio (M‐H, Random, 95% CI)	0.86 [0.59, 1.24]
2.3 Erythromycin	10	718	Odds Ratio (M‐H, Random, 95% CI)	0.73 [0.38, 1.40]
2.4 Roxithromycin	10	3593	Odds Ratio (M‐H, Random, 95% CI)	1.03 [0.76, 1.41]
3 Deaths ‐ subgroup analysis by route of administration	51	214875	Odds Ratio (M‐H, Random, 95% CI)	0.96 [0.87, 1.06]
3.1 Intravenous	8	1334	Odds Ratio (M‐H, Random, 95% CI)	0.83 [0.63, 1.10]
3.2 Peroral	43	213541	Odds Ratio (M‐H, Random, 95% CI)	0.98 [0.88, 1.10]