Pandhi 2014.
Methods | Design: randomised, placebo‐controlled, parallel‐group trial | |
Participants |
Number assigned: 70 children and adults (macrolide n = 35, placebo n = 35) Age in years (mean ± SD): macrolide: 23.00 ± 8.96, placebo: 23.66 ± 8.35 Setting: secondary care |
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Interventions |
Indication: pityriasis rosea Type of macrolide: azithromycin Route: per oral Dose per day: 500 mg (maximum) Duration of treatment: 5 days Total treatment dose: 2500 mg (maximum) |
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Outcomes |
Adverse events stated as an outcome in trial registration/protocol/paper: yes Adverse events ascertainment: participant asked Adverse events: data reported Antimicrobial resistance: not reported Death: not reported |
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Funding sources | None stated. | |
Notes | Concomitant medication: unclear | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated randomisation |
Allocation concealment (selection bias) | Low risk | Central allocation |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Identical‐appearing placebo |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Participants and clinicians blinded. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Low dropout |
Selective reporting (reporting bias) | Low risk | Adverse events stated as an outcome, standardised ascertainment, and adverse events reported. |
Other bias | Low risk | None were identified. |