3. Outcomes for age subgroups in R117H study at 24 weeks.

	Overall		6 ‐ 11 years		≥18 years
	Treatment difference	P value	Treatment difference	P value	Treatment difference	P value
Quality of life (CFQ‐R) ‐ respiratory domain (pooled)	8.4	0.009	‐6.1	0.19	12.6	0.002
% predicted FEV1 ‐ absolute change from baseline	2.1	0.20	‐6.3	0.03	5.0	0.01
% predicted FEV1 ‐ relative change from baseline	5.0	0.06	‐6.8	0.04	0.2	0.008
BMI ‐ absolute change from baseline	0.26	0.78	‐0.18	0.87	0.31	0.78
Sweat chloride ‐ absolute change from baseline	‐24.0	<0.0001	‐27.6	<0.001	‐21.9	<0.001

Treatment difference was adjusted for age and % predicted FEV₁

BMI: body mass index
 CFQ‐R: cystic fibrosis questionnaire ‐ revised
 FEV₁: forced expiratory volume in one second