3. Outcomes for age subgroups in R117H study at 24 weeks.
Overall | 6 ‐ 11 years | ≥18 years | ||||
Treatment difference | P value | Treatment difference | P value | Treatment difference | P value | |
Quality of life (CFQ‐R) ‐ respiratory domain (pooled) | 8.4 | 0.009 | ‐6.1 | 0.19 | 12.6 | 0.002 |
% predicted FEV1 ‐ absolute change from baseline | 2.1 | 0.20 | ‐6.3 | 0.03 | 5.0 | 0.01 |
% predicted FEV1 ‐ relative change from baseline | 5.0 | 0.06 | ‐6.8 | 0.04 | 0.2 | 0.008 |
BMI ‐ absolute change from baseline | 0.26 | 0.78 | ‐0.18 | 0.87 | 0.31 | 0.78 |
Sweat chloride ‐ absolute change from baseline | ‐24.0 | <0.0001 | ‐27.6 | <0.001 | ‐21.9 | <0.001 |
Treatment difference was adjusted for age and % predicted FEV1
BMI: body mass index CFQ‐R: cystic fibrosis questionnaire ‐ revised FEV1: forced expiratory volume in one second