Early stopping
Low risk: sample size calculation was reported and the trial was not stopped, or if the trial was stopped early by formal stopping rules at a point at which the likelihood of observing an extreme intervention effect due to chance was low. Unclear risk: sample size calculation was not reported, and if it is not clear whether or not the trial was stopped early. High risk: the trial was stopped early because of informal stopping rules, or if the trial was stopped early by a formal stopping rule at a point at which the likelihood of observing an extreme intervention effect due to chance was high.	Grade L / U / H
Support for judgement