Secondary outcomes
(dichotomous outcome)		Participants analysed	Number of events in the groups: E = experimental C = control	Bias of the outcome
Lung injury	Maximum follow‐up	E (n)	E (n)	L / U / H
		C (n)	C (n)
	End of trial intervention period	E (n)	E (n)	L / U / H
		C (n)	C (n)
Acute myocardial infarction	Maximum follow‐up	E (n)	E (n)	L / U / H
		C (n)	C (n)
	End of trial intervention period	E (n)	E (n)	L / U / H
		C (n)	C (n)
Stroke	Maximum follow‐up	E (n)	E (n)	L / U / H
		C (n)	C (n)
	End of trial intervention period	E (n)	E (n)	L / U / H
		C (n)	C (n)
Severe sepsis	Maximum follow‐up	E (n)	E (n)	L / U / H
		C (n)	C (n)
	End of trial intervention period	E (n)	E (n)	L / U / H
		C (n)	C (n)