1. Summary of included studies.
| Study ID | Year of studya | Dialysate [Na+] in mM (control/ intervention) | Study design | ITT population (analysed population) | No. analysed in low dialysate [Na+] arm | No. analysed in higher dialysate [Na+] arm | Mean follow‐up (weeks) |
| Akdag 2015 | 2013 | 137/140 | P | 50 (46) | 22 | 24 | 26 |
| Beduschi 2013 | 2013 | 135/138 | P | 52 (38) | 20 | 18 | 16 |
| Boquin 1977 | 1977 | 130/140 | X | 51 (37) | 37 | 37 | 4 |
| Chambers 2002 | 2002 | 136/140b | X | 16 (16) | 16 | 16 | 1 |
| Daugirdas 1985 | 1985 | 135/143 | X | 10 (7) | 7 | 7 | 4 |
| Henrich 1982 | 1982 | 132/144 | X | 10 (10) | 10 | 10 | 6 |
| Liu 2016 | 2016 | 136/138 | P | 64 (57) | 28 | 29 | 52 |
| MATCH‐NA 2015 | 2012 | 134.3/142.9 | X | 18 (16) | 15 | 16 | 1 |
| Ogden 1978 | 1978 | 131/146 | X | 12 (12) | 12 | 12 | 1 |
| Quereda 1988 | 1988 | 133/139 | X | 8 (8) | 8 | 8 | 2 |
| Suckling 2013 | 2013 | 135/145 | X | 10 (10) | 10 | 10 | 1c |
| Van Kuijk 1996 | 1996 | 134/144 | X | 9 (9) | 9 | 9 | 1c |
Abbreviations: X ‐ cross‐over study; P ‐ parallel group study; ITT ‐ intention to treat
a year of patient accrual if available, year of study publication otherwise
b profiled dialysate [Na+]
c one session intervention and follow‐up