6. "Dose effect" for intervention of lower versus higher dialysate [Na+].

Outcome	Overall effect	Neutral dialysate [Na+] (138 to 140 mM)	High dialysate [Na+]	P value*
IDWG	‐0.35 [‐0.51, ‐0.18]	‐0.33 [‐0.51, ‐0.14]	‐0.42 [‐0.80, ‐0.05]	0.65
Predialysis mean MAP	‐3.58 [‐5.46, ‐1.69]	‐3.52 [‐5.46, ‐1.57]	‐4.48 [‐12.07, 3.10]	0.74
Postdialysis mean MAP	‐3.26 [‐4.82, ‐1.70]	‐3.01 [‐4.69, ‐1.34]	‐4.85 [‐9.10, ‐0.60]	0.34
Predialysis serum [Na+]	‐1.69 [‐2.36, ‐1.02]	‐1.59 [‐2.40, ‐0.78]	‐1.92 [‐3.15, ‐0.70]	0.65
Postdialysis serum [Na+]	‐4.74 [‐8.30, ‐1.17]	‐1.80 [‐2.66, ‐0.94]	‐6.75 [‐11.32, ‐2.18]	0.02
Intradialytic cramps	1.77 [1.15, 2.73]	1.66 [0.92, 2.98]	1.94 [1.54, 2.44]	0.63
Intradialytic hypotension	1.52 [1.14, 2.02]	1.49 [1.09, 2.03]	1.71 [0.57, 5.07]	0.81

IDWG ‐ interdialytic weigh gain; MAP pressure

*P values refer to hypothesis testing of the means for "vs. neutral dialysate [Na+]" compared to "vs. high dialysate [Na+]"