| Study | Reason for exclusion |
|---|---|
| Acchiardo 1975 | Wrong intervention: study of what solution to infuse for treatment of cramps |
| AIMS 2011 | Wrong population: HDF rather than HD |
| Bachtiar 2005 | Wrong intervention: tested low dialysate [Na+] versus BIS‐guided target weight adjustment on BP. The dialysate [Na+] in the latter group was not specified. The authors were emailed for clarification but never replied |
| Barre 1988 | Wrong intervention: high dialysate [Na+] versus higher dialysate [Na+] |
| CARNIDIAL 2012 | Wrong intervention: carnitine supplementation |
| Coli 2000 | Wrong intervention: dialysate [Na+] with a co‐intervention of UF profiling |
| De Nicola 2000 | Wrong intervention: neutral dialysate [Na+] versus high dialysate [Na+] |
| de Vries 1990 | Wrong intervention: dialysate [Na+] with a co‐intervention of UF profiling |
| Ebrahimi 2017 | Wrong intervention: dialysate [Na+] not < 138 mM |
| Ekart 2015 | Wrong population: HDF rather than HD |
| Enia 1998 | Wrong population: CAPD patients |
| Ficociello 2012 | Wrong intervention: specific alignment of dialysate [Na+] to serum [Na+] |
| HEMATOL 2013 | Wrong population: critically ill rather than maintenance HD patients |
| Henrich 1983 | Wrong intervention: high sodium bicarbonate and acetate HD |
| Lambie 2005 | Wrong intervention: on‐line conductivity monitoring; did not compare low dialysate [Na+] to medium or high dialysate [Na+] |
| Levin 1996 | Wrong intervention: did not test low dialysate [Na+] |
| Macon 1995 | Wrong intervention: slow HD versus dialysate [Na+] modelling |
| Mahiout 1987 | Wrong intervention: high dialysate [Na+] versus higher dialysate [Na+] |
| Meira 2010 | Wrong intervention: high dialysate [Na+] versus profiled dialysate [Na+] with an average dialysate [Na+] that was also high |
| Moret 2006 | Wrong intervention: neutral dialysate [Na+] versus high dialysate [Na+] |
| NCT01015313 | This study has been withdrawn prior to enrolment |
| NCT01168947 | Wrong intervention: saline versus 5% dextrose as priming and rinsing fluids |
| NCT01766882 | Wrong intervention: goal weight challenging versus dietary sodium restriction in the setting of a fixed dialysate [Na+] of 137 mM |
| Oliver 2001 | Wrong population: effect of low dialysate [Na+] on patients with high or low baseline IDWG |
| Oliver 2001a | Wrong intervention: dialysate [Na+] with a co‐intervention of UF profiling |
| Robberechts 2013 | Wrong intervention: the authors did not define low dialysate [Na+], although the study meets the other criteria to be included in the review. The authors were emailed for clarification but never replied |
| Sandy 1996 | Wrong population: critically ill rather than maintenance HD patients |
| Sang 1997 | Wrong intervention: high dialysate [Na+] to higher dialysate [Na+] |
| Selby 2007 | Wrong intervention: low dialysate [Na+] to lower dialysate [Na+] |
BP ‐ blood pressure; CAPD ‐ continuous ambulatory peritoneal dialysis; HDF ‐ haemodiafiltration; HD ‐ haemodialysis; IDWG ‐ interdialytic weigh gain; UF ‐ ultrafiltration