Comparison 1. Methotrexate versus placebo – major outcomes ≤ 6 months.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Disease response (PsARC)	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2 Function (HAQ)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
3 Disease activity (DAS28‐ESR)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
4 Serious adverse events	3	293	Risk Ratio (M‐H, Random, 95% CI)	0.26 [0.03, 2.26]
5 Withdrawals due to adverse events	3	293	Risk Ratio (M‐H, Random, 95% CI)	1.32 [0.51, 3.42]